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PhD fellowship - University of Bordeaux

We are looking for a highly motivated candidate to work on an interdisciplinary project on the regulation of hematopoietic stem cell differentiation. The candidate will be co-supervised by Dr. Katie Sawai and Dr. Loïc Paulevé at the University of Bordeaux.

Interested and qualified candidates should contact Katie Sawai (catherine.sawai@u-bordeaux.fr) for information on how to apply. A decision will be made no later than July 1st, 2024.

Project description

The hematopoietic system displays a remarkable regenerative capacity throughout the lifetime of an organism. This regeneration is a biologically complex process that is finely regulated by numerous genetic and epigenetic mechanisms that control hematopoietic stem cell self-renewal and differentiation. HemaMoX is an interdisciplinary project that is led by Dr. Katie Sawai (INSERM U1312 BRIC/Université de Bordeaux) and Dr. Loïc Paulevé (LaBRI CNRS UMR 5800/Bordeaux INP/Université de Bordeaux) that aims to combine high resolution single-cell analyses and innovative bioinformatic modeling methods to generate new hypotheses that describe the regulation of stem cell differentiation and how such regulation may change during aging. While some experimental datasets have already been generated and used for modeling, the candidate will generate data on chromatin accessibility profiles (scATAC-seq, BRIC) to be integrated into the models (LaBRI), and eventually experimentally validate candidate genes (BRIC).

 

Qualifications

We are seeking candidates with a solid background in genetics as well as molecular and cellular biology (M2 in cancer, molecular biology, genetics, etc.). Experience with bioinformatic analysis of “omics” data (knowledge of R or other) is strongly preferred. Candidates must be open to working with animals.


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Katie Sawai



U1312 - BRIC | Inserm  | Université de Bordeaux


Bâtiment BBS | 4ème étage, N° 4031


2 rue Dr. Hoffmann Martinot | 33076 Bordeaux


Tél: 05 57 57 10 51

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