Nos expertises

les expertises des membres du bureau du CHO

Les membres du bureau du CHO possèdent tous une grande expertise dans leur domaine.

Nous vous proposons de les découvrir au travers de quelques publications significatives.

Paulo de Sepulveda

Chargé de recherche

CRCM, U1068 INSERM, Marseille

 Equipe Signalisation, Hématopoïèse et mécanismes de l’oncogenèse,

Cancers (Basel). 2020 Jul 21;12(7):1996.
SRC-Family Kinases in Acute Myeloid Leukaemia and Mastocytosis
Edwige Voisset, Fabienne Brenet, Sophie Lopez, Paulo de Sepulveda

J Clin Invest. 2017 Jun 1;127(6):2310-2325. Epub 2017 May 2.
Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma
Michael Olvedy, Julie C Tisserand, Flavie Luciani, Bram Boeckx, Jasper Wouters, Sophie Lopez, Florian Rambow, Sara Aibar, Bernard Thienpont, Jasmine Barra, Corinna Köhler, Enrico Radaelli, Sophie Tartare-Deckert, Stein Aerts, Patrice Dubreuil, Joost J van den Oord, Diether Lambrechts, Paulo De Sepulveda, Jean-Christophe Marine

Nat Commun. 2017 Nov 10;8(1):1420.
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
Kahina Hammam, Magali Saez-Ayala, Etienne Rebuffet, Laurent Gros, Sophie Lopez, Berengere Hajem, Martine Humbert, Emilie Baudelet, Stephane Audebert, Stephane Betzi, Adrien Lugari, Sebastien Combes, Sebastien Letard, Nathalie Casteran, Colin Mansfield, Alain Moussy, Paulo De Sepulveda, Xavier Morelli, Patrice Dubreuil

Oncotarget. 2016 Aug 9;7(32):51163-51173.
An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia
Sophie Lopez, Edwige Voisset, Julie C Tisserand, Cyndie Mosca, Thomas Prebet, David Santamaria, Patrice Dubreuil, Paulo De Sepulveda

Fabienne Meggetto

DR1 CNRS - Toulouse

INSERM-UMR 1037_CNRS-UMR 5071_Université Toulouse III-Paul Sabatier
co-directrice de l'équipe « R’n Blood : Biologie des ARN dans les tumeurs hématologiques », Toulouse

Cancers (Basel). 2021 Jan 5;13(1):144.
NPM-ALK: A Driver of Lymphoma Pathogenesis and a Therapeutic Target
Elissa Andraos, Joséphine Dignac, Fabienne Meggetto

J Clin Invest. 2020 Dec 1;130(12):6395-6408.
ALK-transformed mature T lymphocytes restore early thymus progenitor features
Annabelle Congras, Coralie Hoareau-Aveilla, Nina Caillet, Marie Tosolini, Patrick Villarese, Agata Cieslak, Laura Rodriguez, Vahid Asnafi, Elisabeth Macintyre, Gerda Egger, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

Haematologica. 2019 Feb;104(2):347-359.
miR-497 suppresses cycle progression through an axis involving CDK6 in ALK-positive cells
Coralie Hoareau-Aveilla, Cathy Quelen, Annabelle Congras, Nina Caillet, Delphine Labourdette, Christine Dozier, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

Cancers (Basel). 2017 Aug 3;9(8):100.
Crosstalk between microRNA and DNA Methylation Offers Potential Biomarkers and Targeted Therapies in ALK-Positive Lymphomas
Coralie Hoareau-Aveilla, Fabienne Meggetto

J Clin Invest. 2015 Sep;125(9):3505-18.
Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth
Coralie Hoareau-Aveilla, Thibaud Valentin, Camille Daugrois, Cathy Quelen, Géraldine Mitou, Samuel Quentin, Jinsong Jia, Salvatore Spicuglia, Pierre Ferrier, Monica Ceccon, Sylvie Giuriato, Carlo Gambacorti-Passerini, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

Marie-Laure Arcangeli

Chargée de recherche

Équipe « Thérapies innovantes dans les leucémies myéloïdes et les cellules souches hématopoïétiques »

Centre Méditerranéen de Médecine Moléculaire (C3M) - Nice - INSERM U1274,

Mots Clés :

Cellules souches hématopoïétiques,
autorenouvellement,
ROS,
transformation leucémique

Leukemia. 2022 Aug;36(8):2140-2143.
REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses
Vilma Barroca, Elia Henry, Nathalie Dechamps, Laurent Renou, Paul Chaintreuil, Rohan Kulkarni, Saiyirami Devanand, Arnaud Jacquel, Guillaume Robert, Patrick Auberger, Françoise Pflumio, Marie-Laure Arcangeli

Hemasphere. 2021 Jun 12;5(7):e594.
JAM-C/ Jam-C Expression Is Primarily Expressed in Mouse Hematopoietic Stem Cells
Elia Henry, Vilma Barroca, Cécile K Lopez, Michel Aurrand-Lions, Daniel Lewandowski, Thomas Mercher, Marie-Laure Arcangeli

Exp Hematol. 2020 Jun;86:15-20.e2.
Combined G-CSF and Plerixafor enhance hematopoietic recovery of CD34+ cells from poor mobilizer patients in NSG mice
Marie-Laure Arcangeli, Philippe Brault, Jean-Henri Bourhis, Frédérique Kuhnowskie, Elia Henry, Vilma Barroca, Serge Koscielny, Françoise Pflumio, Sophie Amsellem

Haematologica. 2020 Aug;105(8):2044-2055.
Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations
Elia Henry, Inès Souissi-Sahraoui, Margaux Deynoux, Andréas Lefèvre, Vilma Barroca, Anna Campalans, Véronique Ménard, Julien Calvo, Françoise Pflumio, Marie-Laure Arcangeli

Dominique Baudry-Bluteau

Maitre de conférences, HDR - EPHE, Université PSL
UMR9019 « Genome integrity and Cancers » CNRS/Paris Saclay/Gustave Roussy
Equipe "Mechanisms of DNA repair and Cancers"
Gustave Roussy Cancer Campus, Villejuif.

Mots clés :

Maladies rares
Prédisposition tumorale
Cnacres pédiatriques
Transcription

Haematologica. 2019 Jun;104(6):1244-1255.doi: 10.3324/haematol.2018.188904. Epub 2018 Dec 13.

Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia
Ana C Glembotsky, Dominika Sliwa, Dominique Bluteau, Nathalie Balayn, Cecilia P Marin Oyarzún, Anna Raimbault, Marie Bordas, Nathalie Droin, Iryna Pirozhkova, Valance Washington, Nora P Goette, Rosana F Marta, Rémi Favier, Hana Raslova, Paula G Heller

J Clin Invest. 2016 Sep 1;126(9):3580-4.

Biallelic inactivation of REV7 is associated with Fanconi anemia.
Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois d'Enghien C, Bluteau O, Cuccuini W, Gachet S, Peffault de Latour R, Leblanc T, Socié G, Baruchel A, Stoppa-Lyonnet D, D'Andrea AD, Soulier J.

J Clin Invest. 2014 Feb 3;124(2):580-91.

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.
Bluteau D*, Balduini A*, Balayn N, Currao M, Nurden P, Deswartes C, Leverger G, Noris P, Perotta S, Solary E, Vainchenker W, Debili N, Favier R*, Raslova H*.

Nat Commun. 2012 Mar 6;3:717.

RUNX1-Induced Silencing of Non-Muscle Myosin Heavy Chain IIB Contributes to Megakaryocyte Polyploidization.
L. Lordier*, D. Bluteau*, A. Jalil, C. Legrand, J. Pan, P. Rameau, D. Jouni, O. Bluteau, T. Mercher, C. Leon, C. Gachet, N. Debili, W. Vainchenker, H. Raslova**, Y. Chang**.

Sylvain Lefort

Chargé de recherche

Équipe « BMP, Écosystème, Cellules Souches et Dynamique du Cancer »

Centre de Recherche en Cancérologie de Lyon (CRCL) - Lyon - INSERM U1052 - CNRS 5286

Mots clés :

Microenvironnement de la leucémie,
biomécanique,
résistance aux médicaments,
hétérogénéité cellulaire,
initiation tumorale.

Biomater Sci. 2022 Jan 18;10(2):485-498.doi: 10.1039/d1bm01098k.
A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes
Thibault Voeltzel, Gaëlle Fossard, Michaël Degaud, Kevin Geistlich, Nicolas Gadot, Sandrine Jeanpierre, Ivan Mikaelian , Marie Brevet, Adrienne Anginot, Marie-Caroline Le Bousse-Kerdilès, Valérie Trichet, Sylvain Lefort, Véronique Maguer-Satta

Haematologica. 2021 Jan 1;106(1):111-122.doi: 10.3324/haematol.2019.232793.
The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission
Sandrine Jeanpierre, Kawtar Arizkane, Supat Thongjuea, Elodie Grockowiak, Kevin Geistlich, Lea Barral, Thibault Voeltzel, Anissa Guillemin, Sandrine Gonin-Giraud, Olivier Gandrillon, Franck-Emmanuel Nicolini, Adam J Mead, Véronique Maguer-Satta, Sylvain Lefort

Cell Death Differ. 2022 Jan;29(1):54-64.doi: 10.1038/s41418-021-00836-6. Epub 2021 Jul 22.
De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer
Sylvain Lefort, Amal El-Naggar, Susanna Tan, Shane Colborne, Gian Luca Negri, Davide Pellacani, Martin Hirst, Barry Gusterson, Gregg B Morin, Poul H Sorensen, Connie J Eaves

Oncogene. 2020 Feb;39(9):1957-1968.doi: 10.1038/s41388-019-1111-0. Epub 2019 Nov 26.
Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation
Sylvain Lefort, Susanna Tan, Sneha Balani, Bo Rafn, Davide Pellacani, Martin Hirst, Poul H Sorensen, Connie J Eaves

Amélie Guitart

Chargée de recherche

Équipe « Cellule souches hématopoïétiques normales et leucémiques »

Bordeaux Institute of oncology (BRIC) - Bordeaux
INSERM U1312

Mots clés :

HSC,
FL-HSC,
AML,
modèle de souris,
Métabolisme

Stem Cell Reports. 2021 Nov 9;16(11):2784-2797.doi: 10.1016/j.stemcr.2021.10.001. Epub 2021 Oct 28.
CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation
Hannah Lawson, Louie N van de Lagemaat, Melania Barile, Andrea Tavosanis, Jozef Durko, Arnaud Villacreces, Aarushi Bellani, Christopher Mapperley, Elise Georges, Catarina Martins-Costa, Catarina Sepulveda, Lewis Allen, Joana Campos, Kirsteen J Campbell, Dónal O'Carroll, Berthold Göttgens, Suzanne Cory, Neil P Rodrigues, Amelie V Guitart, Kamil R Kranc

Clin Cancer Res. 2021 Nov 1;27(21):6012-6025.doi: 10.1158/1078-0432.CCR-20-3114. Epub 2021 Aug 16.
Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia
Pierre-Yves Dumas, Arnaud Villacreces, Amélie V Guitart, Ali El-Habhab, Layal Massara, Olivier Mansier, Audrey Bidet, Delphine Martineau, Solene Fernandez, Thibaut Leguay, Arnaud Pigneux, Isabelle Vigon, Jean-Max Pasquet, Vanessa Desplat

Blood. 2019 Dec 26;134(26):2383-2387.doi: 10.1182/blood.2019001163.
Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells
Olivier Mansier, Badr Kilani, Amélie V Guitart, Alexandre Guy, Virginie Gourdou-Latyszenok, Caroline Marty, Marie Parrens, Isabelle Plo, William Vainchenker, Chloé James

J Exp Med. 2017 Mar 6;214(3):719-735.doi: 10.1084/jem.20161087. Epub 2017 Feb 15.
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
Amelie V Guitart, Theano I Panagopoulou, Arnaud Villacreces, Milica Vukovic, Catarina Sepulveda, Lewis Allen, Roderick N Carter, Louie N van de Lagemaat, Marcos Morgan, Peter Giles, Zuzanna Sas, Marta Vila Gonzalez, Hannah Lawson, Jasmin Paris, Joy Edwards-Hicks, Katrin Schaak, Chithra Subramani, Deniz Gezer, Alejandro Armesilla-Diaz, Jimi Wills, Aaron Easterbrook, David Coman, Chi Wai Eric So, Donal O'Carroll, Douglas Vernimmen, Neil P Rodrigues, Patrick J Pollard, Nicholas M Morton, Andrew Finch, Kamil R Kranc

Bastien Gerby

Chargé de recherche

Équipe « Impact des altérations génétiques sur le développement des leucémies aiguës »

Centre de Recherche en Cancérologie de Toulouse (CRCT) - Toulouse - INSERM U1037

Mots clés :

Leucémies aiguës lymphoblastiques B;
Facteur de transcription oncogénique;
Cellules souches pré-leucémiques;
Reprogrammation oncogénique;
Auto-renouvellement;
Initiation et transformation leucémique

Cancers (Basel). 2021 Nov 2;13(21):5511.doi: 10.3390/cancers13215511.
Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells
Vincent Fregona, Manon Bayet, Bastien Gerby

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10357-10362.doi: 10.1073/pnas.1721678115. Epub 2018 Sep 26.
PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice
Laura Jamrog, Guillaume Chemin, Vincent Fregona, Lucie Coster, Marlène Pasquet, Chloé Oudinet, Nelly Rouquié, Naïs Prade, Stéphanie Lagarde, Charlotte Cresson, Sylvie Hébrard, Ngoc Sa Nguyen Huu, Marina Bousquet, Cathy Quelen, Pierre Brousset, Stéphane J C Mancini, Eric Delabesse, Ahmed Amine Khamlichi, Bastien Gerby, Cyril Broccardo

J Clin Invest. 2016 Dec 1;126(12):4569-4584.doi: 10.1172/JCI86489. Epub 2016 Oct 31.
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells
Bastien Gerby, Diogo F T Veiga, Jana Krosl, Sami Nourreddine, Julianne Ouellette, André Haman, Geneviève Lavoie, Iman Fares, Mathieu Tremblay, Véronique Litalien, Elizabeth Ottoni, Milena Kosic, Dominique Geoffrion, Joël Ryan, Paul S Maddox, Jalila Chagraoui, Anne Marinier, Josée Hébert, Guy Sauvageau, Benjamin H Kwok, Philippe P Roux, Trang Hoang

PLoS Genet. 2014 Dec 18;10(12):e1004768.doi: 10.1371/journal.pgen.1004768. eCollection 2014 Dec.
SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells
Bastien Gerby, Cedric S Tremblay, Mathieu Tremblay, Shanti Rojas-Sutterlin, Sabine Herblot, Josée Hébert, Guy Sauvageau, Sébastien Lemieux, Eric Lécuyer, Diogo F T Veiga, Trang Hoang

Pierre Sujobert

PU-PH - Hématologue

Service d’Hématologie biologique - Hospices Civils de Lyon

Centre Hospitalier Lyon Sud (HCL) - Lyon
Centre International de Recherche en Infectiologie,
INSERM U1111

Mots clés :

Lymphome,
BTG1,
kambo,
AML,
Vexas

Blood. 2022 Nov 14;blood.2022016943.doi: 10.1182/blood.2022016943. Online ahead of print.
BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1
Lorric Delage, Mireille Lambert, Emilie Bardel, Cindy Kundlacz, Dimitri Chartoire, Axel Conchon, Anne-Laure Peugnet, Lucas Gorka, Patrick Auberger, Arnaud Jacquel, Carole Soussain, Olivier Destaing, Henri-Jacques Delecluse, Susanne Delecluse, Samir Merabet, Alexandra Traverse-Glehen, Gilles A Salles, Emmanuel Bachy, Marc Billaud, Herve Ghesquieres, Laurent Genestier, Jean Pierre Rouault, Pierre Sujobert

Blood. 2022 Aug 25;140(8):927-931.doi: 10.1182/blood.2022016642.
Ruxolitinib is more effective than other JAK inhibitors to treat VEXAS syndrome: a retrospective multicenter study
Maël Heiblig, Marcela A Ferrada, Matthew J Koster, Thomas Barba, Mathieu Gerfaud-Valentin, Arsène Mékinian, Henrique Coelho, Gaelle Fossard, Fiorenza Barraco, Lionel Galicier, Boris Bienvenu, Pierre Hirsch, Guillaume Vial, Anne Blandine Boutin, Joris Galland, Guillaume Le Guenno, Adrien Bigot, Kenneth J Warrington, Tanaz A Kermani, Peter C Grayson, Bhavisha A Patel, David B Beck, Yvan Jamilloux, Pierre Fenaux, Pierre Sujobert

Haematologica. 2022 Jun 1;107(6):1466-1469.doi: 10.3324/haematol.2022.280406.
Diagnosis of acute promyelocytic leukemia based on routine biological parameters using machine learning
Estelle Cheli, Simon Chevalier, Olivier Kosmider, Marion Eveillard, Nicolas Chapuis, Adriana Plesa, Maël Heiblig, Lydie Andre, Jenny Pouget, Pascal Mossuz, Olivier Theisen, Vincent Alcazer, Dan Gugenheim, Nicolas Autexier, Pierre Sujobert

Hemasphere. 2021 Aug 10;5(9):e629.doi: 10.1097/HS9.0000000000000629. eCollection 2021 Sep.
How to Transform an Exceptional Case Report Into a Therapy: Following the Frog Out of the Box
Maël Heiblig, Vincent Alcazer, Adriana Plesa, Hélène Labussière-Wallet, Pierre Sujobert

Françoise Porteu

Directrice de recherche

Équipe « Cellules souches et développement des hémopathies myéloïdes »

Institut Gustave Roussy (IGR) - Villejuif - INSERM U1287

Mots clés :

Cellules souches hématopoïétiques ;
épigénétique ;
signalisation ;
vieillissement ;
MDS

J Exp Med. 2022 Aug 1;219(8):e20211356.
NF-κB signaling controls H3K9me3 levels at intronic LINE-1 and hematopoietic stem cell genes in cis
Yanis Pelinski, Donia Hidaoui, Anne Stolz, François Hermetet, Rabie Chelbi, M'boyba Khadija Diop, Amir M Chioukh, Françoise Porteu, Emilie Elvira-Matelot

J Exp Med. 2018 May 7;215(5):1463-1480.
Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response
Daniela Barbieri, Emilie Elvira-Matelot, Yanis Pelinski, Laetitia Genève, Bérengère de Laval, Gayathri Yogarajah, Christian Pecquet, Stefan N Constantinescu, Françoise Porteu

Stem Cell Reports. 2016 Jun 14;6(6):970-984.
Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation
Dounia Djeghloul, Klaudia Kuranda, Isabelle Kuzniak, Daniela Barbieri, Irina Naguibneva, Caroline Choisy, Jean-Christophe Bories, Christine Dosquet, Marika Pla, Valérie Vanneaux, Gérard Socié, Françoise Porteu, David Garrick, Michele Goodhardt

Cell Stem Cell. 2013 Jan 3;12(1):37-48.
Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage
Bérengère de Laval 1 , Patrycja Pawlikowska, Laurence Petit-Cocault, Chrystèle Bilhou-Nabera, Geneviève Aubin-Houzelstein, Michèle Souyri, Frédéric Pouzoulet, Murielle Gaudry, Françoise Porteu

Catherine Sawai

Chargée de recherche

Équipe « Modélisation des mécanismes de transformation et de résistance dans la leucémie »
Bordeaux Institute of oncology (BRIC) - Bordeaux
INSERM U1312

Mots clés :

Cellules souches hématopoïétiques ;
vieillissement,
leucémie,
in vivo

Curr Opin Hematol. 2020 Jul;27(4):241-247.
In-vivo differentiation of adult hematopoietic stem cells from a single-cell point of view
Amal Nazaraliyev 1 , Elodie Richard, Catherine M Sawai

J Exp Med. 2018 Nov 5;215(11):2815-2832.
Kinetics of adult hematopoietic stem cell differentiation in vivo
Samik Upadhaya, Catherine M Sawai, Efthymia Papalexi, Ali Rashidfarrokhi, Geunhyo Jang, Pratip Chattopadhyay, Rahul Satija, Boris Reizis

Cell Stem Cell. 2020 Aug 6;27(2):336-345.e4.
Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche
Samik Upadhaya, Oleg Krichevsky, Ilseyar Akhmetzyanova, Catherine M Sawai, David R Fooksman, Boris Reizis

Immunity. 2016 Sep 20;45(3):597-609.
Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals
Catherine M Sawai, Sonja Babovic, Samik Upadhaya, David J H F Knapp, Yonit Lavin, Colleen M Lau, Anton Goloborodko, Jue Feng, Joji Fujisaki, Lei Ding, Leonid A Mirny, Miriam Merad, Connie J Eaves, Boris Reizis