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Nos expertises

les expertises des membres du bureau du CHO

Les membres du bureau du CHO possèdent tous une grande expertise dans leur domaine.

 

Nous vous proposons de les découvrir au travers de quelques publications significatives.

Paulo de Sepulveda

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Chargé de recherche

CRCM, U1068 INSERM, Marseille


Equipe Signalisation, Hématopoïèse et mécanismes de l’oncogenèse,

Cancers (Basel). 2020 Jul 21;12(7):1996.
SRC-Family Kinases in Acute Myeloid Leukaemia and Mastocytosis
Edwige Voisset, Fabienne Brenet, Sophie Lopez, Paulo de Sepulveda

J Clin Invest. 2017 Jun 1;127(6):2310-2325. Epub 2017 May 2.
Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma
Michael Olvedy, Julie C Tisserand, Flavie Luciani, Bram Boeckx, Jasper Wouters, Sophie Lopez, Florian Rambow, Sara Aibar, Bernard Thienpont, Jasmine Barra, Corinna Köhler, Enrico Radaelli, Sophie Tartare-Deckert, Stein Aerts, Patrice Dubreuil, Joost J van den Oord, Diether Lambrechts, Paulo De Sepulveda, Jean-Christophe Marine

Nat Commun. 2017 Nov 10;8(1):1420.
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
Kahina Hammam, Magali Saez-Ayala, Etienne Rebuffet, Laurent Gros, Sophie Lopez, Berengere Hajem, Martine Humbert, Emilie Baudelet, Stephane Audebert, Stephane Betzi, Adrien Lugari, Sebastien Combes, Sebastien Letard, Nathalie Casteran, Colin Mansfield, Alain Moussy, Paulo De Sepulveda, Xavier Morelli, Patrice Dubreuil


Oncotarget. 2016 Aug 9;7(32):51163-51173.
An essential pathway links FLT3-ITD, HCK and CDK6 in acute myeloid leukemia
Sophie Lopez, Edwige Voisset, Julie C Tisserand, Cyndie Mosca, Thomas Prebet, David Santamaria, Patrice Dubreuil, Paulo De Sepulveda

Philippe Brunet de la Grange

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Directeur de Recherche EFS Bordeaux

Département Scientifique Etablissement français du & INSERM U1035 - Equipe « Cellules Souches Hématopoïétiques Normales et Leucémiques »


 

Leukemia. 2020 Dec;34(12):3370-3381.
Characteristics of cells with engraftment capacity within CD34+ cell population upon G-CSF and Plerixafor mobilization.
Mombled M, Rodriguez L, Avalon M, Duchez P, Vlaski-Lafarge M, Debeissat C, Pérard B, Sawai KM, Pasquet JM, Bijou F, Thévenot F, Cabantous T, Ivanovic Z, Brunet de la Grange P.


Haematologica.
2018 Oct;103(10):1604-1615.

Repopulating hematopoietic stem cells from steady-state blood before and after ex vivo culture are enriched in the CD34+CD133+CXCR4low fraction.
Lapostolle V, Chevaleyre J, Duchez P, Rodriguez L, Vlaski-Lafarge M, Sandvig I, Brunet de la Grange P, Ivanovic Z.

J Cell Physiol. 2018 Jan;233(1):338-349.

Steady state peripheral blood provides cells with functional and metabolic characteristics of real hematopoietic stem cells.
Bourdieu A, Avalon M, Lapostolle V, Ismail S, Mombled M, Debeissat C, Guérinet M, Duchez P, Chevaleyre J, Vlaski-Lafarge M, Villacreces A, Praloran V, Ivanovic Z, Brunet de la Grange P.

Fabienne Meggetto

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DR1 CNRS - Toulouse


INSERM-UMR 1037_CNRS-UMR 5071_Université Toulouse III-Paul Sabatier
co-directrice de l'équipe « R’n Blood : Biologie des ARN dans les tumeurs hématologiques », Toulouse

 

Cancers (Basel). 2021 Jan 5;13(1):144.
NPM-ALK: A Driver of Lymphoma Pathogenesis and a Therapeutic Target
Elissa Andraos, Joséphine Dignac, Fabienne Meggetto

J Clin Invest. 2020 Dec 1;130(12):6395-6408.
ALK-transformed mature T lymphocytes restore early thymus progenitor features
Annabelle Congras, Coralie Hoareau-Aveilla, Nina Caillet, Marie Tosolini, Patrick Villarese, Agata Cieslak, Laura Rodriguez, Vahid Asnafi, Elisabeth Macintyre, Gerda Egger, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

 

Haematologica. 2019 Feb;104(2):347-359.
miR-497 suppresses cycle progression through an axis involving CDK6 in ALK-positive cells
Coralie Hoareau-Aveilla, Cathy Quelen, Annabelle Congras, Nina Caillet, Delphine Labourdette, Christine Dozier, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

Cancers (Basel). 2017 Aug 3;9(8):100.
Crosstalk between microRNA and DNA Methylation Offers Potential Biomarkers and Targeted Therapies in ALK-Positive Lymphomas
Coralie Hoareau-Aveilla, Fabienne Meggetto


J Clin Invest. 2015 Sep;125(9):3505-18.
Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth
Coralie Hoareau-Aveilla, Thibaud Valentin, Camille Daugrois, Cathy Quelen, Géraldine Mitou, Samuel Quentin, Jinsong Jia, Salvatore Spicuglia, Pierre Ferrier, Monica Ceccon, Sylvie Giuriato, Carlo Gambacorti-Passerini, Pierre Brousset, Laurence Lamant, Fabienne Meggetto

Christel Guillouf

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Directrice de recherche

INSERM U1170 - Villejuif

Equipe  "Hématopoïèse normale et pathoplogique"

Mots Clés :

  • Facteur de transcription ETS, SPI1/PU.1,

  • Régulation des ARN (Transcription, Epissage, Epigénétique...),

  • Leucémie myéloïde,

  • érythroleucémie

Cancer Discov. 2019 Jun;9(6):796-811.
A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation
Damien Roos-Weil, Camille Decaudin, Marine Armand, Véronique Della-Valle, M'boyba K Diop, Hussein Ghamlouch, Virginie Ropars, Cécile Hérate, Diane Lara, Eric Durot, Rima Haddad, Elena Mylonas, Frederik Damm, Francoise Pflumio, Bilyana Stoilova, Marlen Metzner, Olivier Elemento, Philippe Dessen, Valérie Camara-Clayette, François-Loïc Cosset, Els Verhoeyen, Véronique Leblond, Vincent Ribrag, Pascale Cornillet-Lefebvre, Philippe Rameau, Nabih Azar, Frédéric Charlotte, Pierre Morel, Jean-Baptiste Charbonnier, Paresh Vyas, Thomas Mercher, Said Aoufouchi, Nathalie Droin, Christel Guillouf, Florence Nguyen-Khac, Olivier A Bernard

 

Haematologica. 2017 Nov;102(11):1850-1860.
Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells
Laure Delestré, Hengxiang Cui, Michela Esposito, Cyril Quiveron, Elena Mylonas, Virginie Penard-Lacronique , Oliver Bischof, Christel Guillouf

 

Cell Death Differ. 2013 Sep;20(9):1268-78.
Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia
M Ridinger-Saison, E Evanno, I Gallais, P Rimmelé, D Selimoglu-Buet, E Sapharikas, F Moreau-Gachelin, C Guillouf


Nucleic Acids Res. 2019 May 21;47(9):4509-4520.
PLZF limits enhancer activity during hematopoietic progenitor aging
Mathilde Poplineau, Julien Vernerey, Nadine Platet, Lia N'guyen, Léonard Hérault, Michela Esposito, Andrew J Saurin, Christel Guilouf, Atsushi Iwama, Estelle Duprez

Marie-Bérangère Troadec

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Présidente

PU-PH CHRU Brest
UMR 1078 INSERM/EFS/UBO -

Equipe « Epissage et Cancer ».

Mots Clés :

  •  syndromes myélodysplasiques

  • leucémies aiguës lymphoblastiques de l’enfant

  • facteurs de transcription et régulateurs transcriptionnels: RUNX1, CBFA2T3, FUBP1, ETV6, ETV6-RUNX1

  • épissage

  • génétique moléculaire et génétique chromosomique

  • métabolisme du fer

Journal of Hematology and Oncology 2021 in press

Reduction of RunX1 transcription factor'activity by a CBFA2T3-Mimicking peptide :  application to B cell precursor acute lymphoblastic leukemia.

Jakobczyk H, Debaize L, Soubise B, Avner S, Rouger-Gaudichon J, Commet S, Jiang Y, Serandour AS, Rio AG, Carroll JS, Wichmann C, Lie-a-Ling M, Lacaud G, Corcos L, Salbert G, Galibert MD, Gandemer V, Troadec MB

Cancers (Basel). 2021 Jan 27;13(3):481.

Asian Population Is More Prone to Develop High-Risk Myelodysplastic Syndrome, Concordantly with Their Propensity to Exhibit High-Risk Cytogenetic Aberrations.

Jiang Y, Eveillard JR, Couturier MA, Soubise B, Chen JM, Gao S, Basinko A, Morel F, Douet-Guilbert N, Troadec MB.

Leukemia. 2020 Jun;34(6):1711-1713

Recommendations for cytogenomic analysis of hematologic malignancies: comments from the Francophone Group of Hematological Cytogenetics (GFCH).

Nguyen-Khac F, Bidet A, Veronese L, Daudignon A, Penther D, Troadec MB, Lefebvre C, Lafage-Pochitaloff M.

Blood Rev. 2020 Jan;39:100617

Too much iron : a masked foe for Leukemias.

Brissot E, Bernard DG, Loréal O, Brissot P, Troadec MB.

Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228

Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation.

Debaize L, Jakobczyk H, Gaudichon J,  Avner S, Rio AG, Serandour AS, Lena Dorsheimer, Frédéric Chalmel, Jason S. Carroll, Martin Zörnig, Michael A. Rieger, Olivier Delalande, Salbert G, Galibert MD, Gandemer V, Troadec MB.

Marie-Laure Arcangeli

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Secrétaire-adjoint

Chargée de recherche Fontenay aux Roses

INSERM U1274,

Equipe : "Laboratoire des cellules Souches Hématopoïétiques et des Leucémies"

Mots Clés :

  • Hématopoïèse,

  • cellules souches hématopoïétiques,

  • auto-renouvellement,

  • transformation leucémique,

  • expansion ex vivo des CSH,

  • Transplantation,

  • modèles animaux,

  • xénogreffe (NSG),

  • Lymphopoïèse T extra et intrathymique,

  • microenvironnement et ROS

Exp Hematol. 2021;94:11-9

How Hematopoietic Stem Cells Respond to Irradiation: Similarities and Differences between Low and High Doses of Ionizing Radiations.

Henry E, Arcangeli M.


Blood Adv. 2021;5(2):523-6.

Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loop.

Fahy L, Calvo J, Chabi S, Renou L, Le Maout C, Poglio S, Leblanc T, Petit A, Baruchel A, Ballerini P, Naguibneva I, Haddad R, Arcangeli ML, Mazurier F, Pflumio F, B. U.


J Leukoc Biol. 2020;107(1):27-42.

Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF-A2 humanized mice resemble those in human samples.

Labarthe L, Henriquez S, Lambotte O, Di Santo JP, Le Grand R, Pflumio F, Arcangeli ML, Legrand N, Bourgeois C.


Haematologica. 2020;105(8):2044-55.

PMCID: PMC7395291.Human hematopoietic stem/progenitor cells display reactive oxygen species-dependent long-term hematopoietic defects after exposure to low doses of ionizing radiations.

Henry E, Souissi-Sahraoui I, Deynoux M, Lefevre A, Barroca V, Campalans A, Menard V, Calvo J, Pflumio F, Arcangeli ML.

Exp Hematol. 2020.

Combined G-CSF and Plerixafor enhance hematopoietic recovery of CD34(+) cells from poor mobilizer patients in NSG mice.

Arcangeli ML, Brault P, Bourhis JH, Kuhnowskie F, Henry E, Barroca V, Koscielny S, Pflumio F, Amsellem S.

Cyril Broccardo

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Secrétaire

DR2 Inserm -  Toulouse

INSERM-UMR 1037_CNRS-UMR 5071_Université Toulouse III-Paul Sabatier

Equipe "ALTFAL : Altération des facteurs de transcription dans les leucémies aigües", Toulouse

Blood, 2020 Oct 9. ahead of print.
Germline PAX5 mutation predisposes to familial B acute lymphoblastic leukemia.
Duployez N, Jamrog L, Fregona V, Hamelle C, Fenwarth L, Lejeune S, Helevaut N, Geffroy S, Caillault Venet A, Marceau-Renaut A, Poulain S, Roche-Lestienne C, Largeaud L, Prade N, Dufrechou S, Hébrard S, Berthon C, Nelken B, Fernandes J, Villenet C, Figeac M, Gerby B, Delabesse E, Preudhomme C, Broccardo C.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10357-10362.
PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice.
Jamrog L, Chemin G, Fregona V, Coster L, Pasquet M, Oudinet C, Rouquié N, Prade N, Lagarde S, Cresson C, Hébrard S, Nguyen Huu NS, Bousquet M, Quelen C, Brousset P, Mancini SJC, Delabesse E, Khamlichi AA, Gerby B, Broccardo C.

Oncotarget. 2018 Aug 28;9(67):32841-32854.
PAX5A and PAX5B isoforms are both efficient to drive B cell differentiation. Cresson C, Péron S, Jamrog L, Rouquié N, Prade N, Dubois M, Hébrard S, Lagarde S, Gerby B, Mancini SJC, Cogné M, Delabesse E, Delpy L, Broccardo C.

Leukemia, 2017 Mar;31(3):565-572.
NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.
Struski, S; Lagarde, S; Bories, P; Puiseux, C; Prade, N; Cuccuini, W; Pages, M P; Bidet, A; Gervais, C; Lafage-Pochitaloff, M; Roche-Lestienne, C; Barin, C; Penther, D; Nadal, N; Radford-Weiss, I; Collonge-Rame, M A; Gaillard, B; Mugneret, F; Lefebvre, C; Bart-Delabesse, E; Petit, A; Leverger, G; Broccardo, C; Luquet, I; Pasquet, M; Delabesse, E.

Dominique Bluteau

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Maitre de conférences, HDR - EPHE, Université PSL
UMR9019 « Genome integrity and Cancers » CNRS/Paris Saclay/Gustave Roussy
Equipe "Mechanisms of DNA repair and Cancers"
Gustave Roussy Cancer Campus, Villejuif.

Mots clés :

  • Prédisposition génétique aux cancers,

  • Hématopoïèse, Oncogenèse,

  • DNA repair,

  • Fanconi Anemia,

  • RUNX1,

  • WT1.

Haematologica. 2019 Jun;104(6):1244-1255.

TREM-like transcript (TLT)-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia.
Glembotsky AC*, Sliwa D*, Bluteau D*, Balayn N, Marin Oyarzún CP, Raimbault A, Bordas M, Droin N, Pirozhkova I, Washington V, Goette NP, Marta RF, Favier R, Raslova H, Heller PG. Downregulation of

Genet Med. 2018 Apr;20(4):458-463.

Biallelic truncating FANCM mutations cause early-onset cancer but not Fanconi anemia.
Bogliolo M*, Bluteau D*, Lespinasse J, Pujol R, Vasquez N, d'Enghien CD, Stoppa-Lyonnet D, Leblanc T, Soulier J, Surrallés J.

 
J Clin Invest. 2016 Sep 1;126(9):3580-4.  

Biallelic inactivation of REV7 is associated with Fanconi anemia.
Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois d'Enghien C, Bluteau O, Cuccuini W, Gachet S, Peffault de Latour R, Leblanc T, Socié G, Baruchel A, Stoppa-Lyonnet D, D'Andrea AD, Soulier J.
 
J Clin Invest. 2014 Feb 3;124(2):580-91.

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.
Bluteau D*, Balduini A*, Balayn N, Currao M, Nurden P, Deswartes C, Leverger G, Noris P, Perotta S, Solary E, Vainchenker W, Debili N, Favier R*, Raslova H*.

Nat Commun. 2012 Mar 6;3:717.

RUNX1-Induced Silencing of Non-Muscle Myosin Heavy Chain IIB Contributes to Megakaryocyte Polyploidization.
L. Lordier*, D. Bluteau*, A. Jalil, C. Legrand, J. Pan, P. Rameau, D. Jouni, O. Bluteau, T. Mercher, C. Leon, C. Gachet, N. Debili, W. Vainchenker, H. Raslova**, Y. Chang**.