Postdoc position on deregulated mRNA transcription and protein translation in T-cell leukemia
Postdoc position on deregulated mRNA transcription and protein translation in T-cell leukemia development
The laboratory for Disease Mechanisms in Cancer (KU Leuven, Belgium) is looking for a motivated postdoctoral researcher, to perform research on the biology of T-cell acute lymphoblastic leukemia (T-ALL) within the framework of a research consortium consisting of 5 Belgian research teams.
T-ALL hijacks normal T-cell development pathways to cause a malignant disease. From the numerousstudies on the genomic changes that occur in T-ALL, it is clear that chromatin structure, transcriptionand translation are major processes that are deregulated in T-ALL. However, how specific mutationscooperate and interact to change the cellular mRNA and protein metabolism remains poorly studied. Inthis project, we aim to deconvolute T-ALL development at single-cell resolution in accurate mousemodels of T-ALL by mapping chromatin, transcriptional and protein changes from the early stages ofleukemia initiation to the progression towards acute disease. Lab webpage: www.LDMC.be
How to apply:
You can apply for this job no later than March 20th 2023 via the online application tool: https://www.kuleuven.be/personeel/jobsite/jobs/60192092